Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MGLL | Q99685 | 15/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 6/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785782 | 0.88 | MGLL (0.41) | ALDH1A1MGLLABHD6PLA2G7KDM4E | |
| SCHEMBL19785787 | 0.84 | MGLL (0.41) | ALDH1A1MGLLABHD6PLA2G7KDM4E | |
| SCHEMBL19785873 | 0.84 | VEGFA (0.51) | ALDH1A1MGLLABHD6PLA2G7KDM4E | |
| SCHEMBL29613591 | 0.83 | PTGDR2 (0.44) | — | |
| SCHEMBL19785590 | 0.83 | PTGDR2 (0.44) | — | |
| SCHEMBL19785970 | 0.82 | CTSB (0.45) | ALDH1A1MGLLABHD6PLA2G7KDM4E | |
| SCHEMBL22383724 | 0.77 | GRIN2B (0.55) | ALDH1A1KDM4ETSHR | |
| SCHEMBL18658594 | 0.77 | RORC (0.55) | ALDH1A1KDM4ETSHRMTNR1B | |
| SCHEMBL20614093 | 0.76 | ALDH1A1 (0.48) | ALDH1A1KDM4EPOLB | |
| SCHEMBL30642978 | 0.74 | RORC (0.49) | ALDH1A1KDM4ETSHRMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484880-B1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA AS (DK) | 2020-09-02 | — | — | EP | disclosed |
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |