Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MGLL | Q99685 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785987 | 0.85 | CTSB (0.46) | CTSBALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL18658598 | 0.85 | VEGFA (0.48) | CTSBALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL21368976 | 0.84 | PTGDR2 (0.42) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL29613545 | 0.84 | PTGDR2 (0.42) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL19785591 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KDM4EMGLLABHD6PLA2G7 | |
| SCHEMBL30643025 | 0.76 | MEN1 (0.50) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL29133046 | 0.76 | MEN1 (0.50) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL19785782 | 0.73 | MGLL (0.41) | ALDH1A1KDM4EMGLLABHD6PLA2G7 | |
| SCHEMBL21354265 | 0.72 | PTGDR2 (0.46) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL19785985 | 0.72 | ALDH1A1 (0.45) | CTSBALDH1A1KDM4ETDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484880-B1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA AS (DK) | 2020-09-02 | — | — | EP | disclosed |
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |