SCHEMBL19786083

SCHEMBL19786083

C=CCSS/C=C/CSc1ccc(OC)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
TP53 P04637 4/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
CYP3A4 P08684 1/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
ALOX12 P18054 1/20 0.40
NPC1 O15118 3/20 0.39
RAB9A P51151 2/20 0.39
HPGD P15428 2/20 0.39
APP P05067 1/20 0.38
PTGS2 P35354 1/20 0.37
KDM4E B2RXH2 2/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
MTNR1A P48039 1/20 0.35
MTNR1B P49286 1/20 0.35
CYP1A1 P04798 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP1B1 Q16678 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19786023 1.00 ALDH1A1 (0.40) ALDH1A1TP53SMN1; SMN2CYP3A4ALOX15
SCHEMBL19785866 0.83 MTNR1A (0.40) ALDH1A1PTGS2MAOAMAOBMTNR1A
SCHEMBL19786117 0.83 MTNR1A (0.40) ALDH1A1PTGS2MAOAMAOBMTNR1A
SCHEMBL19786005 0.82 ALDH1A1 (0.38) ALDH1A1TP53SMN1; SMN2CYP3A4NPC1
SCHEMBL19785903 0.82 ALDH1A1 (0.38) ALDH1A1TP53SMN1; SMN2CYP3A4NPC1
SCHEMBL3890971 0.82 TP53 (0.52) ALDH1A1TP53SMN1; SMN2CYP3A4ALOX15
SCHEMBL21189915 0.80 PTGS2 (0.42) ALDH1A1CYP3A4ALOX15NPC1RAB9A
SCHEMBL19785630 0.80 PTGS2 (0.42) ALDH1A1CYP3A4ALOX15NPC1RAB9A
SCHEMBL19785644 0.79 APP (0.44) ALDH1A1TP53TSHRNPC1RAB9A
SCHEMBL19786132 0.79 APP (0.44) ALDH1A1TP53TSHRNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019143143-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEUROBLASTOMA OR RHEUMATOID ARTHRITIS 숙명여자대학교 산학협력단 2019-07-25 WO disclosed
WO-2018012947-A1 NOVEL ORGANIC SULFUR COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER OR AN INFLAMMATORY DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT 숙명여자대학교 산학협력단 2018-01-18 WO disclosed