Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.71 |
| ▸ | CDK4 | P11802 | 5/20 | 0.67 |
| ▸ | CCND1 | P24385 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609618 | 1.00 | SIRT1 (0.71) | SIRT1CDK4CCND1NPC1RAB9A | |
| SCHEMBL761706 | 0.79 | MEN1 (0.75) | SIRT1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL17037428 | 0.78 | MEN1 (0.70) | SIRT1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5459439 | 0.77 | SIRT1 (0.61) | SIRT1CDK4CCND1NPC1RAB9A | |
| SCHEMBL5459435 | 0.77 | SIRT1 (0.61) | SIRT1CDK4CCND1NPC1RAB9A | |
| SCHEMBL12894877 | 0.77 | GOT1 (0.67) | CDK4CCND1NPC1RAB9AMEN1 | |
| SCHEMBL18595162 | 0.75 | MEN1 (0.76) | SIRT1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6365945 | 0.74 | MEN1 (0.65) | SIRT1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4331421 | 0.74 | MEN1 (1.00) | SIRT1CDK4CCND1NPC1RAB9A | |
| SCHEMBL7677879 | 0.74 | MEN1 (0.67) | SIRT1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393787-B1 | CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2018-01-24 | — | — | EP | disclosed |