Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.61 |
| ▸ | CDK4 | P11802 | 4/20 | 0.58 |
| ▸ | CCND1 | P24385 | 4/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.49 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NMBR | P28336 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459435 | 1.00 | SIRT1 (0.61) | SIRT1CDK4CCND1BCHEACHE | |
| SCHEMBL5455335 | 0.87 | NMBR (0.52) | CDK4CCND1MEN1KMT2ANPC1 | |
| SCHEMBL5470683 | 0.82 | KMT2A (0.53) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5470684 | 0.82 | KMT2A (0.53) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8115065 | 0.81 | NMBR (0.72) | SIRT1HDAC3HDAC1HDAC2MAPT | |
| SCHEMBL8609618 | 0.77 | SIRT1 (0.71) | SIRT1CDK4CCND1BCHEACHE | |
| SCHEMBL19789867 | 0.77 | SIRT1 (0.71) | SIRT1CDK4CCND1BCHEACHE | |
| SCHEMBL8115465 | 0.75 | CA1 (0.53) | MEN1KMT2AMAPT | |
| SCHEMBL20168557 | 0.72 | SPR (0.61) | SIRT1CDK4CCND1ACHETRPV1 | |
| SCHEMBL20168558 | 0.72 | SPR (0.61) | SIRT1CDK4CCND1ACHETRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293530-A1 | SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | METHYLGENE INC. (CA) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293530-A1 | SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HAT1 | SIRT1 34/4885CDK4 1939/4885CCND1 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.