Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.51 |
| ▸ | PLG | P00747 | 5/20 | 0.49 |
| ▸ | PLAT | P00750 | 5/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12278423 | 1.00 | F2 (0.51) | F2PLGPLATPRSS1PSMB5 | |
| SCHEMBL24530135 | 0.81 | PIN1 (0.53) | HDAC2HDAC8HDAC6ALDH1A1CYP2C19 | |
| SCHEMBL29144589 | 0.81 | PIN1 (0.53) | HDAC2HDAC8HDAC6ALDH1A1CYP2C19 | |
| SCHEMBL12279818 | 0.76 | CTRB1 (0.56) | PSMB5PSMB8 | |
| SCHEMBL24530131 | 0.76 | YAP1 (0.49) | HDAC6ALDH1A1CYP2C19HDAC1SMN1; SMN2 | |
| SCHEMBL7029711 | 0.75 | LTA4H (0.60) | ALDH1A1CYP2C19 | |
| SCHEMBL24629308 | 0.73 | SMN1; SMN2 (0.53) | F2PLGPLATPRSS1PSMB5 | |
| SCHEMBL24702730 | 0.73 | SMN1; SMN2 (0.53) | F2PLGPLATPRSS1PSMB5 | |
| SCHEMBL25682253 | 0.73 | SMN1; SMN2 (0.57) | F2PLGPLATPRSS1PSMB5 | |
| SCHEMBL9389851 | 0.73 | ALDH1A1 (0.51) | HDAC2HDAC8HDAC6ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552216-B1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARM INC (US) | 2018-01-24 | — | — | EP | disclosed |