Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23705578 | 0.82 | PKM (0.62) | PKMALDH1A1STSLMNAHPGD | |
| SCHEMBL19791804 | 0.80 | FBP1 (0.47) | PKMALDH1A1STSCA2CA12 | |
| SCHEMBL19791849 | 0.77 | CES1 (0.41) | PKMALDH1A1CA2CA12CA1 | |
| SCHEMBL19791803 | 0.77 | CA2 (0.56) | PKMALDH1A1STSCA2CA12 | |
| SCHEMBL1366438 | 0.75 | PKM (1.00) | PKMALDH1A1CA12CA9LMNA | |
| SCHEMBL4513102 | 0.74 | ALDH1A1 (0.75) | PKMALDH1A1CA2CA1LMNA | |
| SCHEMBL6898963 | 0.72 | PKM (0.50) | PKMALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL9918671 | 0.71 | — | — | |
| SCHEMBL22306542 | 0.69 | PKM (0.44) | PKMALDH1A1CA2CA12CA1 | |
| SCHEMBL28865400 | 0.68 | ALDH1A1 (0.40) | PKMALDH1A1CA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018015445-A1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | NodThera Limited (GB) | 2018-01-25 | — | — | WO | disclosed |
| EP-3272739-A1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | NodThera Limited (GB) | 2018-01-24 | — | — | EP | disclosed |
| EP-3272739-A1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | NodThera Limited (GB) | 2018-01-24 | — | — | EP | disclosed |