Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19897390 | 0.82 | TSHR (0.50) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL19794523 | 0.82 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2TSHRENPP3 | |
| SCHEMBL17968220 | 0.78 | MAPK1 (0.48) | NPC1RAB9ASMN1; SMN2TSHRHPGD | |
| SCHEMBL20022148 | 0.78 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2TSHRHPGD | |
| SCHEMBL4266240 | 0.78 | CLK4 (0.43) | TSHRALDH1A1TRPA1CTSDBACE1 | |
| SCHEMBL5085077 | 0.76 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2TSHRHPGD | |
| SCHEMBL20022131 | 0.76 | ENPP3 (0.49) | NPC1RAB9ASMN1; SMN2TSHRHPGD | |
| SCHEMBL20022100 | 0.76 | ENPP3 (0.49) | NPC1RAB9ASMN1; SMN2TSHRHPGD | |
| SCHEMBL31097920 | 0.75 | SMN1; SMN2 (0.37) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL3361069 | 0.74 | HTR7 (0.43) | NPC1RAB9ASMN1; SMN2CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | NPC1 2761/4885RAB9A 1433/4885SMN1; SMN2 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.