Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984297 | 0.88 | RAB9A (0.46) | ALDH1A1KDM4EACACBRAB9AMEN1 | |
| SCHEMBL17350123 | 0.79 | RORC (0.41) | CASP1RORCBRAFPTGS1FFAR1 | |
| SCHEMBL1982041 | 0.77 | XIAP (0.44) | CASP1RORCBRAFPTGS1FFAR1 | |
| SCHEMBL1978975 | 0.77 | RAB9A (0.48) | ALDH1A1KDM4EACACBRAB9ANPC1 | |
| SCHEMBL21980919 | 0.77 | CASP1 (0.41) | CASP1RORCBRAFPTGS1FFAR1 | |
| SCHEMBL13720514 | 0.77 | CASP1 (0.41) | CASP1RORCBRAFPTGS1FFAR1 | |
| SCHEMBL1979333 | 0.75 | RAB9A (0.43) | RORCFFAR1ALDH1A1KDM4EACACB | |
| SCHEMBL13832422 | 0.75 | JAK2 (0.41) | CASP1RORCBRAFKDM4EMEN1 | |
| SCHEMBL1982040 | 0.73 | SYK (0.44) | CASP1RORCBRAFPTGS1ALDH1A1 | |
| SCHEMBL17354614 | 0.72 | RXRA (0.48) | RORCPTGS1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509961-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | Autifony Therapeutics Limited (GB) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011069951-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |