Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.44 |
| ▸ | PTAFR | P25105 | 2/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979171 | 0.90 | WNT1 (0.42) | TLR7TLR9TLR8PTAFRWNT1 | |
| SCHEMBL1979088 | 0.87 | WNT1 (0.51) | TLR7TLR9TLR8WNT1DYRK1A | |
| SCHEMBL1980360 | 0.87 | KMT2A (0.48) | — | |
| SCHEMBL1979499 | 0.87 | KMT2A (0.48) | — | |
| SCHEMBL12598121 | 0.86 | KDM4E (0.44) | TLR7TLR9TLR8WNT1DYRK1A | |
| SCHEMBL12598125 | 0.86 | DRD2 (0.48) | TLR7TLR9TLR8PTAFRWNT1 | |
| SCHEMBL1983761 | 0.85 | BRAF (0.47) | TLR7TLR9BRAFPTAFRWNT1 | |
| SCHEMBL473719 | 0.85 | BRAF (0.47) | TLR7TLR9TLR8BRAFEGLN1 | |
| SCHEMBL1981803 | 0.85 | MTNR1A (0.45) | TLR7TLR9TLR8BRAFPTAFR | |
| SCHEMBL12597820 | 0.84 | TLR9 (0.40) | TLR7TLR9TLR8CHRNB1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |