Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.33 |
| ▸ | LATS1 | O95835 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19805011 | 0.86 | GABRG2 (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL21310437 | 0.83 | AAK1 (0.39) | GABRG2GABRB3GABRA5HSP90AA1HSP90AB1 | |
| SCHEMBL19806740 | 0.81 | DDB1 (0.42) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL22960801 | 0.79 | MAPT (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL16637427 | 0.79 | MAPT (0.41) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL29773883 | 0.77 | CHRM2 (0.49) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL21308367 | 0.76 | MAPT (0.36) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL16597821 | 0.75 | GABRG2 (0.42) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL21217178 | 0.74 | GABRG2 (0.40) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL22978317 | 0.74 | GABRG2 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306093-B2 | Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3′,4′-d]pyrrole | HOFFMANN-LA ROCHE, INC. (US) | 2022-04-19 | — | — | US | disclosed |
| US-11058781-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. | 2021-07-13 | — | — | US | disclosed |
| EP-3510031-B1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | HOFFMANN LA ROCHE (CH) | 2020-12-02 | — | — | EP | disclosed |
| EP-3510031-B1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | HOFFMANN LA ROCHE (CH) | 2020-12-02 | — | — | EP | disclosed |
| US-20190300529-A1 | Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole | HOFFMANN-LA ROCHE INC. (US) | 2019-10-03 | — | — | US | disclosed |
| US-20190300529-A1 | Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole | HOFFMANN-LA ROCHE INC. (US) | 2019-10-03 | — | — | US | disclosed |
| EP-3510031-A1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | H. Hoffnabb-La Roche Ag (CH) | 2019-07-17 | — | — | EP | disclosed |
| US-20180326099-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN-LA ROCHE INC. (US) | 2018-11-15 | — | — | US | disclosed |
| US-10004817-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. (US) | 2018-06-26 | — | — | US | disclosed |
| WO-2018046428-A1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018046428-A1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-15 | — | — | WO | disclosed |
| EP-3055308-B1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN LA ROCHE (CH) | 2017-11-22 | — | — | EP | disclosed |
| EP-3055308-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | F.HOFFMANN-LA ROCHE AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052105-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10004817-B2 | Diazacarbazole derivatives as tau-PET-ligands | SNCA, MAPT, PSEN1 | GABRG2 724/4885GABRB3 55/4885GABRA5 292/4885 |
| US-20180326099-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | SNCA, MAPT, PSEN1 | GABRG2 724/4885GABRB3 55/4885GABRA5 292/4885 |
| US-11058781-B2 | Diazacarbazole derivatives as tau-PET-ligands | SNCA, MAPT, PSEN1 | GABRG2 724/4885GABRB3 55/4885GABRA5 292/4885 |
| US-20190300529-A1 | Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole | HBB, PAH, BOLA2; BOLA2B | GABRG2 345/4885GABRB3 233/4885GABRA5 611/4885 |
| US-11306093-B2 | Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3′,4′-d]pyrrole | HBB, PAH, BOLA2; BOLA2B | GABRG2 341/4885GABRB3 239/4885GABRA5 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.