Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22960801 | 0.90 | MAPT (0.39) | MAPTBTKGPR119GABRG2GABRB3 | |
| SCHEMBL21308367 | 0.85 | MAPT (0.36) | MAPTBTKGPR119GABRG2GABRB3 | |
| SCHEMBL21310437 | 0.83 | AAK1 (0.39) | MAPTGPR119GABRG2GABRB3GABRA5 | |
| SCHEMBL19805011 | 0.79 | GABRG2 (0.37) | BTKGPR119GABRG2GABRB3GABRA5 | |
| SCHEMBL16637537 | 0.79 | GABRG2 (0.37) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL22907143 | 0.79 | MAPT (0.53) | MAPTJAK2RETKDRGSK3A | |
| SCHEMBL29547252 | 0.79 | MAPT (0.53) | MAPTJAK2RETKDRGSK3A | |
| SCHEMBL19806740 | 0.77 | DDB1 (0.42) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL18012185 | 0.73 | GABRG2 (0.41) | MAPTBTKGPR119GABRG2GABRB3 | |
| SCHEMBL29773883 | 0.71 | CHRM2 (0.49) | GPR119GABRG2GABRB3GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11058781-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. | 2021-07-13 | — | — | US | claimed |
| US-20180326099-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN-LA ROCHE INC. (US) | 2018-11-15 | — | — | US | claimed |
| US-11058781-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. | 2021-07-13 | — | — | US | disclosed |
| US-20210047327-A1 | DIAGNOSTIC COMPOSITIONS FOR PET IMAGING, A METHOD FOR MANUFACTURING THE DIAGNOSTIC COMPOSITION AND ITS USE IN DIAGNOSTICS | LIFE MOLECULAR IMAGING LIMITED (GB) | 2021-02-18 | — | — | US | disclosed |
| US-20210038747-A1 | NOVEL METHOD OF PREPARING AN IMAGING COMPOUND | LIFE MOLECULAR IMAGING LIMITED (GB) | 2021-02-11 | — | — | US | disclosed |
| US-10865207-B2 | Compounds for imaging Tau protein aggregates | AC IMMUNE S.A. (CH) | 2020-12-15 | — | — | US | disclosed |
| US-10835624-B2 | Compounds for imaging Tau protein aggregates | AC IMMUNE S.A. (CH) | 2020-11-17 | — | — | US | disclosed |
| US-20190262480-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | Lantheus Biosciences Ltd. (GB) | 2019-08-29 | — | — | US | disclosed |
| US-20190263817-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | Lantheus Biosciences Ltd. (GB) | 2019-08-29 | — | — | US | disclosed |
| WO-2019145294-A1 | NOVEL METHOD OF PREPARING AN IMAGING COMPOUND | AC IMMUNE SA (CH) | 2019-08-01 | — | — | WO | disclosed |
| WO-2019145293-A1 | DIAGNOSTIC COMPOSITIONS FOR PET IMAGING, A METHOD FOR MANUFACTURING THE DIAGNOSTIC COMPOSITION AND ITS USE IN DIAGNOSTICS | AC IMMUNE SA (CH) | 2019-08-01 | — | — | WO | disclosed |
| US-20180326099-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN-LA ROCHE INC. (US) | 2018-11-15 | — | — | US | disclosed |
| US-10004817-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. (US) | 2018-06-26 | — | — | US | disclosed |
| WO-2018015549-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | AC IMMUNE S.A. (CH) | 2018-01-25 | — | — | WO | disclosed |
| WO-2018015546-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | AC IMMUNE S.A. (CH) | 2018-01-25 | — | — | WO | disclosed |
| EP-3055308-B1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN LA ROCHE (CH) | 2017-11-22 | — | — | EP | disclosed |
| EP-3055308-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | F.HOFFMANN-LA ROCHE AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052105-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190262480-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | MAPT, PSEN2, PSEN1 | MAPT 1/4885BTK 4542/4885GRIA1 910/4885 |
| US-10835624-B2 | Compounds for imaging Tau protein aggregates | MAPT, PSEN2, PSEN1 | MAPT 1/4885BTK 4542/4885GRIA1 910/4885 |
| US-10004817-B2 | Diazacarbazole derivatives as tau-PET-ligands | SNCA, MAPT, PSEN1 | MAPT 2/4885BTK 2942/4885GRIA1 1442/4885 |
| US-20180326099-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | SNCA, MAPT, PSEN1 | MAPT 2/4885BTK 2942/4885GRIA1 1442/4885 |
| US-20210047327-A1 | DIAGNOSTIC COMPOSITIONS FOR PET IMAGING, A METHOD FOR MANUFACTURING THE DIAGNOSTIC COMPOSITION AND ITS USE IN DIAGNOSTICS | MAPT, PSEN1, APP | MAPT 1/4885BTK 4677/4885GRIA1 1097/4885 |
| US-10865207-B2 | Compounds for imaging Tau protein aggregates | MAPT, PSEN1, PSEN2 | MAPT 1/4885BTK 4547/4885GRIA1 660/4885 |
| US-11058781-B2 | Diazacarbazole derivatives as tau-PET-ligands | SNCA, MAPT, PSEN1 | MAPT 2/4885BTK 2942/4885GRIA1 1442/4885 |
| US-20190263817-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | MAPT, PSEN1, PSEN2 | MAPT 1/4885BTK 4547/4885GRIA1 660/4885 |
| US-20210038747-A1 | NOVEL METHOD OF PREPARING AN IMAGING COMPOUND | MAPT, PSEN2, PSEN1 | MAPT 1/4885BTK 4778/4885GRIA1 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.