Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16242607 | 0.85 | POLB (0.57) | SMN1; SMN2SLC1A2MAPTKMT2ACYP1A2 | |
| SCHEMBL19821082 | 0.84 | DAO (0.51) | SMN1; SMN2SLC1A2MAPTKMT2ACYP1A2 | |
| SCHEMBL17226236 | 0.84 | KMT2A (0.54) | SMN1; SMN2MAPTKMT2AHPGDALDH1A1 | |
| SCHEMBL10847537 | 0.80 | DAO (0.51) | SMN1; SMN2SLC1A2MAPTKMT2ACYP1A2 | |
| SCHEMBL29700326 | 0.80 | POLB (0.61) | SMN1; SMN2MAPTKMT2ACYP1A2CYP3A4 | |
| SCHEMBL6916799 | 0.80 | POLB (0.61) | SMN1; SMN2MAPTKMT2ACYP1A2CYP3A4 | |
| Naphthalene SCHEMBL28721345 | 0.79 | MGAM (0.45) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL775626 | 0.78 | TAAR1 (0.50) | SMN1; SMN2MAPTKMT2ACYP1A2CYP3A4 | |
| SCHEMBL777337 | 0.78 | ALDH1A1 (0.56) | SMN1; SMN2MAPTKMT2ACYP1A2CYP2C9 | |
| SCHEMBL9770355 | 0.78 | HTR7 (0.48) | SMN1; SMN2MAPTALDH1A1LMNAMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180030003-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030003-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | NR1H4, SLC10A1, SLC10A2 | SMN1; SMN2 4144/4885SLC1A2 799/4885MAPT 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.