Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19830031 | 1.00 | SIGMAR1 (0.43) | SIGMAR1KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19827902 | 1.00 | SIGMAR1 (0.43) | SIGMAR1KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19827901 | 0.80 | MAOB (0.61) | MAOAMAOBBCHEACHEADRA2B | |
| SCHEMBL19830037 | 0.80 | MAOB (0.61) | MAOAMAOBBCHEACHEADRA2B | |
| SCHEMBL19830012 | 0.80 | MAOB (0.61) | MAOAMAOBBCHEACHEADRA2B | |
| SCHEMBL17753765 | 0.78 | PDPK1 (0.55) | SIGMAR1SLC6A2SLC6A4SLC6A3MAOA | |
| SCHEMBL12228573 | 0.78 | SIGMAR1 (0.55) | SIGMAR1KDM1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL19810475 | 0.77 | PDPK1 (0.53) | SLC6A2SLC6A4ADRA2BADRA2CADRA1A | |
| SCHEMBL19828084 | 0.76 | POLB (0.43) | SIGMAR1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL172262 | 0.76 | MAOA (0.64) | SIGMAR1KDM1AHTR1AHTTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | PGI DRUG DISCOVERY LLC | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | ACHE, CHAT, MAOB | SIGMAR1 1203/4885KDM1A 4074/4885SLC6A2 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.