SCHEMBL19831040

SCHEMBL19831040

CCOC(=O)c1c(C(=O)c2ccc(OC)cc2)c2ccc(Cl)cc2n1-c1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 5/20 0.52
USP14 P54578 2/20 0.49
HPGD P15428 1/20 0.48
MAPK1 P28482 1/20 0.46
PTGS2 P35354 1/20 0.46
P2RX3 P56373 1/20 0.45
MAPT P10636 3/20 0.44
RAB9A P51151 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
ALDH1A1 P00352 1/20 0.44
PPARG P37231 1/20 0.44
ABCB1 P08183 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19831032 0.93 MAPK1 (0.52) MAPK8USP14HPGDMAPK1ALDH1A1
SCHEMBL19831035 0.88 MAPK8 (0.51) MAPK8MAPK1MAPTALDH1A1
SCHEMBL19831041 0.87 MAPK8 (0.52) MAPK8USP14HPGDMAPTRAB9A
SCHEMBL19831065 0.85 MAPK8 (0.47) MAPK8HPGDMAPK1P2RX3MAPT
SCHEMBL19831212 0.85 MAPK8 (0.50) MAPK8USP14MAPK1ALDH1A1
SCHEMBL19831072 0.85 MAPK1 (0.48) MAPK8USP14HPGDMAPK1MAPT
SCHEMBL19831089 0.84 MAPK1 (0.50) MAPK8USP14HPGDMAPK1MAPT
SCHEMBL19831099 0.83 ELANE (0.48) MAPK8HPGDMAPTALDH1A1PPARG
SCHEMBL19831214 0.81 PPARG (0.53) MAPK8CYP1A2CYP2C9CYP2C19PPARG
SCHEMBL19831091 0.78 ELANE (0.54) HPGDMAPK1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018021762-A1 NOVEL COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 현대약품 주식회사 2018-02-01 WO disclosed