Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL11061842 | 1.00 | — | — | |
| Water SCHEMBL2299753 | 1.00 | — | — | |
| Water SCHEMBL94343 | 1.00 | — | — | |
| Water SCHEMBL8477073 | 1.00 | — | — | |
| Water SCHEMBL8745540 | 1.00 | — | — | |
| Water SCHEMBL11059872 | 1.00 | — | — | |
| Water SCHEMBL3644096 | 1.00 | — | — | |
| Water SCHEMBL9297984 | 1.00 | — | — | |
| Water SCHEMBL5802169 | 1.00 | — | — | |
| Water SCHEMBL8153667 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253330-B | Novel crystal form of sartan drug, preparation method and application thereof | 广州白云山天心制药股份有限公司 | 2023-01-24 | — | — | CN | claimed |
| EP-1124567-B2 | BUFFERED COMPOSITIONS FOR DIALYSIS | ADVANCED RENAL TECHNOLOGIES (US) | 2011-06-29 | — | — | EP | claimed |
| EP-1124567-B1 | BUFFERED COMPOSITIONS FOR DIALYSIS | ADVANCED RENAL TECHNOLOGIES (US) | 2006-03-29 | — | — | EP | claimed |
| EP-4691459-A1 | COMBINATION FORMULATION COMPRISING SACUBITRIL-VALSARTAN AND SGLT-2 INHIBITOR HAVING IMPROVED STABILITY AND DISSOLUTION RATE | Hanmi Pharm. Co., Ltd. (KR) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024210557-A1 | COMBINATION FORMULATION COMPRISING SACUBITRIL-VALSARTAN AND SGLT-2 INHIBITOR HAVING IMPROVED STABILITY AND DISSOLUTION RATE | 한미약품 주식회사 | 2024-10-10 | — | — | WO | disclosed |
| CN-111253330-B | Novel crystal form of sartan drug, preparation method and application thereof | 广州白云山天心制药股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-111253330-B | Novel crystal form of sartan drug, preparation method and application thereof | 广州白云山天心制药股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-111253330-A | Novel crystal form of sartan drug, preparation method and application thereof | 广州白云山天心制药股份有限公司 | 2020-06-09 | — | — | CN | disclosed |
| CN-106905253-B | Crystallization of supramolecular complexes | 正大天晴药业集团股份有限公司 | 2020-01-03 | — | — | CN | disclosed |
| CN-106905253-B | Crystallization of supramolecular complexes | 正大天晴药业集团股份有限公司 | 2020-01-03 | — | — | CN | disclosed |
| WO-2019180735-A1 | STABLE PHARMACEUTICAL COMPOSITIONS COMPRISING SACUBITRIL-VALSARTAN COMPLEX | NATCO PHARMA LIMITED (IN) | 2019-09-26 | — | — | WO | disclosed |
| US-4181634-A | Mild cleansing compositions comprising an alkyleneoxylated bisquaternary ammonium compound and an anionic or amphoteric detergent such as a phosphobetaine | JOHNSON & JOHNSON (US) | 1980-01-01 | — | — | US | disclosed |