Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15782821 | 0.88 | KMT2A (0.44) | MEN1KMT2ATSHRCYP3A4CLK1 | |
| SCHEMBL8567650 | 0.80 | KDM4E (0.42) | KDM4EMEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL2647896 | 0.77 | THRA (0.48) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL955961 | 0.76 | CYP2C19 (0.49) | KDM4EALDH1A1HSD17B10MEN1HPGD | |
| SCHEMBL305877 | 0.76 | HCRTR1 (0.54) | KDM4EALDH1A1HSD17B10MEN1HPGD | |
| SCHEMBL4841763 | 0.74 | NPC1 (0.57) | ALDH1A1MEN1HPGDHTTKMT2A | |
| SCHEMBL4097250 | 0.74 | MAPT (0.50) | ALDH1A1MEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL25355846 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1HSD17B10MEN1HPGD | |
| SCHEMBL7866445 | 0.73 | TSHR (0.40) | KDM4EALDH1A1HSD17B10MEN1HPGD | |
| SCHEMBL8045140 | 0.73 | L3MBTL1 (0.39) | KDM4EALDH1A1HSD17B10HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884830-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-02-06 | — | — | US | disclosed |