Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27923133 | 1.00 | TSHR (0.40) | TSHRPTGDR2PTGS2PDCD1CD274 | |
| SCHEMBL2062407 | 0.81 | PTGDR2 (0.39) | PTGDR2PTGS2ADRA2ACYP1A2CYP2D6 | |
| SCHEMBL2062913 | 0.81 | PTGDR2 (0.39) | PTGDR2PTGS2ADRA2ACYP1A2CYP2D6 | |
| SCHEMBL9203356 | 0.77 | PTGDR2 (0.41) | PTGDR2PTGS2ADRA2ACYP1A2CYP2D6 | |
| SCHEMBL7496181 | 0.75 | ADRA2A (0.40) | PTGDR2PTGS2ADRA2ACYP1A2CYP2D6 | |
| SCHEMBL11663955 | 0.75 | PTGDR2 (0.38) | PTGDR2PTGS2ADRA2ACYP1A2CYP2D6 | |
| SCHEMBL11663952 | 0.74 | PTGDR2 (0.41) | PTGDR2PTGS2ADRA2ACYP1A2CYP2D6 | |
| SCHEMBL11366017 | 0.74 | PTGS2 (0.43) | PTGDR2PTGS2ADRA2ACYP1A2CYP2D6 | |
| Hydrogen Peroxide SCHEMBL11527811 | 0.74 | PTGDR2 (0.44) | TSHRPTGDR2PTGS2ADRA2ACYP1A2 | |
| SCHEMBL198311 | 0.73 | PTGDR2 (0.48) | PTGDR2PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040038419-A1 | Assays and kits for detecting the presence of nitriles and/or cyanide | DIVERSA CORPORATION | 2004-02-26 | — | — | US | claimed |
| WO-2003098187-A2 | ASSAYS AND KITS FOR DETECTING THE PRESENCE OF NITRILES AND/OR CYANIDE | DIVERSA CORPORATION (US) | 2003-11-27 | — | — | WO | claimed |
| US-9828594-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2017-11-28 | — | — | US | disclosed |
| US-20160355801-A1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | VERENIUM CORPORATION | 2016-12-08 | — | — | US | disclosed |
| US-9315792-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2016-04-19 | — | — | US | disclosed |
| CN-105296512-A | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC | 2016-02-03 | — | — | CN | disclosed |
| US-9217164-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2015-12-22 | — | — | US | disclosed |
| EP-2327766-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-12-02 | — | — | EP | disclosed |
| CN-102796750-B | The nucleic acid of nitrilase, encoding nitrilase enzyme, and the method preparing and use them | BASF ENZYMES LLC (US) | 2015-09-16 | — | — | CN | disclosed |
| EP-2319919-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-1576108-B1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | BASF ENZYMES LLC (US) | 2015-07-08 | — | — | EP | disclosed |
| EP-1578910-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1576108-A2 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | DIVERSA CORPORATION (US) | 2005-09-21 | — | — | EP | disclosed |
| US-20040038419-A1 | Assays and kits for detecting the presence of nitriles and/or cyanide | DIVERSA CORPORATION | 2004-02-26 | — | — | US | disclosed |
| US-20040014195-A1 | Nitrilases, nucleic acids encoding them and methods for making and using them | DIVERSA CORPORATION (US) | 2004-01-22 | — | — | US | disclosed |
| US-20040002147-A1 | Nitrilases | DIVERSA CORPORATION | 2004-01-01 | — | — | US | disclosed |
| WO-2003097810-A2 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | DIVERSA CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003098187-A2 | ASSAYS AND KITS FOR DETECTING THE PRESENCE OF NITRILES AND/OR CYANIDE | DIVERSA CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| US-20030124698-A1 | Which stereoselectively hydrolyze nitrites or cyanohydrins into acids and ammonia | DIVERSA CORPORATION | 2003-07-03 | — | — | US | disclosed |
| WO-2003000840-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014195-A1 | Nitrilases, nucleic acids encoding them and methods for making and using them | RNGTT, NSUN2, NSUN3 | TSHR 4156/4885PTGDR2 4544/4885PTGS2 2070/4885 |
| US-20040002147-A1 | Nitrilases | RNGTT, DNTT, NOP2 | TSHR 4001/4885PTGDR2 4450/4885PTGS2 1656/4885 |
| US-20030124698-A1 | Which stereoselectively hydrolyze nitrites or cyanohydrins into acids and ammonia | NIT2, DNPH1, ASNS | TSHR 4562/4885PTGDR2 4308/4885PTGS2 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.