Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | VCP | P55072 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.58 |
| ▸ | MAOA | P21397 | 3/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.57 |
| ▸ | MPL | P40238 | 2/20 | 0.56 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29276772 | 0.92 | AGER (0.75) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL28908960 | 0.90 | AGER (0.62) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL205404 | 0.88 | VCP (0.65) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL205146 | 0.87 | AGER (0.65) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL206171 | 0.86 | ALOX5 (0.60) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL207176 | 0.86 | AGER (0.61) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL7113308 | 0.86 | CYP1B1 (0.67) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL19851003 | 0.85 | CTRB1 (0.64) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL205667 | 0.83 | AGER (0.55) | AGERRAB9ANPC1MEN1KMT2A | |
| SCHEMBL16603960 | 0.83 | AGER (1.00) | AGERRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947207-B2 | GP130 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190292161-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-09-26 | — | — | US | disclosed |
| WO-2018027193-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292161-A1 | GP130 MODULATORS | GRIN2A, GRIA4, GRIA3 | AGER 67/4885RAB9A 2645/4885NPC1 1149/4885 |
| US-10947207-B2 | GP130 modulators | GRIN2A, GRIA4, GRIA3 | AGER 67/4885RAB9A 2645/4885NPC1 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.