Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18927451 | 0.89 | FOLH1 (0.38) | FOLH1EPHX2MAPK1 | |
| SCHEMBL12891858 | 0.85 | ALDH1A1 (0.39) | FOLH1 | |
| SCHEMBL7923259 | 0.85 | ALDH1A1 (0.39) | FOLH1 | |
| SCHEMBL20718666 | 0.84 | ACACB (0.39) | — | |
| SCHEMBL18927429 | 0.79 | KMT2A (0.40) | GRM5CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL116795 | 0.79 | ABCB11 (0.39) | FOLH1EPHX2MAPK1CYP3A4CYP2A6 | |
| SCHEMBL21946939 | 0.78 | HRH1 (0.36) | — | |
| SCHEMBL24859291 | 0.78 | ESR1 (0.38) | MAPK1CYP3A4CYP2C19ESR1ESR2 | |
| SCHEMBL18897125 | 0.78 | DGAT1 (0.38) | CYP3A4 | |
| SCHEMBL18891695 | 0.78 | ESR1 (0.38) | MAPK1CYP3A4CYP2C19ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190150445-A1 | SUBSTITUTED HALOGEN(THIO)ACYL COMPOUNDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-05-23 | — | — | US | disclosed |
| US-10239859-B2 | Nitrogen-containing heterocycles as pesticides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-03-26 | — | — | US | disclosed |
| US-10196399-B2 | Metabotrophic glutamate receptor 5 modulators and methods use thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20180201600-A1 | NITROGEN-CONTAINING HETEROCYCLES AS PESTICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-07-19 | — | — | US | disclosed |
| US-20180037585-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS USE THEREOF | SUNOVION PHARAMCEUTICALS INC. | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196399-B2 | Metabotrophic glutamate receptor 5 modulators and methods use thereof | GRM5, GRIK5, GRM2 | FOLH1 155/4885EPHX2 2551/4885GRM5 1/4885 |
| US-20180201600-A1 | NITROGEN-CONTAINING HETEROCYCLES AS PESTICIDES | DDT, DNPH1, PTMS | FOLH1 2369/4885EPHX2 355/4885GRM5 1627/4885 |
| US-20180037585-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS USE THEREOF | GRM5, GRIK5, GRM2 | FOLH1 155/4885EPHX2 2551/4885GRM5 1/4885 |
| US-10239859-B2 | Nitrogen-containing heterocycles as pesticides | DDT, DNPH1, PTMS | FOLH1 2369/4885EPHX2 355/4885GRM5 1627/4885 |
| US-20190150445-A1 | SUBSTITUTED HALOGEN(THIO)ACYL COMPOUNDS | ACOT7, AGPAT5, TST | FOLH1 4376/4885EPHX2 2881/4885GRM5 2205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.