Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19839342 | 0.84 | RIPK1 (0.46) | RIPK1SIGMAR1OPRM1OPRL1MEN1 | |
| SCHEMBL19853780 | 0.82 | MEN1 (0.46) | RIPK1SIGMAR1OPRM1OPRL1MEN1 | |
| SCHEMBL19839918 | 0.78 | GAA (0.49) | RIPK1OPRM1OPRL1GAAMEN1 | |
| SCHEMBL19853779 | 0.78 | GAA (0.51) | RIPK1SIGMAR1OPRM1OPRL1GAA | |
| SCHEMBL19853665 | 0.77 | GAA (0.48) | RIPK1OPRM1OPRL1GAAMEN1 | |
| SCHEMBL19839346 | 0.77 | GAA (0.48) | RIPK1OPRM1OPRL1GAAMEN1 | |
| SCHEMBL19853693 | 0.76 | RIPK1 (0.48) | RIPK1OPRM1OPRL1KMT2ACHRM2 | |
| SCHEMBL21326821 | 0.74 | TDP1 (0.47) | RIPK1SIGMAR1OPRM1OPRL1GAA | |
| SCHEMBL19853781 | 0.74 | MMP1 (0.50) | RIPK1SIGMAR1OPRM1OPRL1GAA | |
| SCHEMBL19838842 | 0.74 | GAA (0.48) | RIPK1SIGMAR1OPRM1OPRL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |