Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856883 | 0.91 | ALOX15 (0.42) | DRD3STAT6CYP51A1DRD2ALOX15 | |
| SCHEMBL19856882 | 0.91 | ALOX15 (0.42) | DRD3STAT6CYP51A1DRD2ALOX15 | |
| SCHEMBL19856871 | 0.91 | DRD2 (0.41) | PDGFRBPDGFRASTAT6CYP51A1DRD2 | |
| SCHEMBL19856872 | 0.91 | DRD2 (0.41) | PDGFRBPDGFRASTAT6CYP51A1DRD2 | |
| SCHEMBL1549612 | 0.91 | PDGFRB (0.48) | NPC1RAB9APDGFRBFLT3PDGFRA | |
| SCHEMBL19856942 | 0.90 | DRD2 (0.42) | PDGFRBPDGFRADRD3STAT6CYP51A1 | |
| SCHEMBL19856943 | 0.90 | DRD2 (0.42) | PDGFRBPDGFRADRD3STAT6CYP51A1 | |
| SCHEMBL1550637 | 0.89 | PDGFRB (0.48) | NPC1RAB9APDGFRBFLT3PDGFRA | |
| SCHEMBL19856916 | 0.88 | CYP51A1 (0.40) | STAT6CYP51A1DRD2TAS1R3TAS1R1 | |
| SCHEMBL19856914 | 0.88 | CYP51A1 (0.40) | STAT6CYP51A1DRD2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |