Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 6/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3306573 | 0.84 | MAOA (0.50) | CRBNMAOAALDH1A1KDM4EMRGPRX1 | |
| SCHEMBL2260801 | 0.81 | CRBN (0.46) | CRBNMAOAALDH1A1MRGPRX1MAOB | |
| SCHEMBL30367973 | 0.81 | ALDH1A1 (0.62) | LCKADORA2AADORA2BADORA1PARP1 | |
| SCHEMBL28258201 | 0.80 | CRBN (0.54) | CRBNMAOAALDH1A1KDM4EGAA | |
| SCHEMBL3965575 | 0.80 | CRBN (0.48) | CRBNMAOAALDH1A1KDM4EMRGPRX1 | |
| SCHEMBL25649885 | 0.79 | PARP1 (0.51) | LCKADORA2AADORA2BADORA1PARP1 | |
| SCHEMBL21039188 | 0.78 | ALDH1A1 (0.51) | LCKADORA2AADORA2BADORA1PARP1 | |
| SCHEMBL29891436 | 0.78 | ALDH1A1 (0.51) | LCKADORA2AADORA2BADORA1PARP1 | |
| SCHEMBL28633012 | 0.77 | LCK (0.48) | LCKADORA2AADORA2BADORA1PARP1 | |
| SCHEMBL28629962 | 0.77 | LCK (0.48) | LCKADORA2AADORA2BADORA1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515679-A | Heterocyclic amides and their use for modulating splicing | 雷密克斯医疗公司 | 2022-12-23 | — | — | CN | disclosed |
| US-10174005-B2 | Fused pyrimidines as inhibitors of p97 complex | CLEAVE BIOSCIENCES, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180044325-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | CLEAVE BIOSCIENCES, INC. | 2018-02-15 | — | — | US | disclosed |
| CN-107406434-A | As 5 HT4The amide compound of receptor stimulating agent | 苏文生命科学有限公司 | 2017-11-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174005-B2 | Fused pyrimidines as inhibitors of p97 complex | WDR77, POP1, PSMG3 | LCK 3174/4885ADORA2A 4380/4885ADORA2B 4408/4885 |
| US-20180044325-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | WDR77, POP1, PSMG3 | LCK 3181/4885ADORA2A 4381/4885ADORA2B 4399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.