Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19858913 | 0.82 | RPS6KA2 (0.49) | ROCK2PTK2AURKACCNA2CDK2 | |
| SCHEMBL19858911 | 0.80 | AURKA (0.52) | STK10SLKROCK2MAPTSMN1; SMN2 | |
| SCHEMBL2581867 | 0.77 | METAP2 (0.53) | ROCK2MAPTROCK1GAAALDH1A1 | |
| SCHEMBL10784214 | 0.73 | ALDH1A1 (0.57) | MAPTSMN1; SMN2PTK2KDM4EMEN1 | |
| SCHEMBL10784705 | 0.72 | GAA (0.57) | MAPTSMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL12492054 | 0.72 | TTK (0.80) | AURKACCNA2CDK2TTK | |
| SCHEMBL17276860 | 0.70 | AKT2 (0.56) | ROCK2MAPTROCK1GAAALDH1A1 | |
| SCHEMBL10785269 | 0.70 | GAA (0.70) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL7261506 | 0.69 | ADRA1D (0.48) | ROCK2PTK2AURKAJAK2JAK3 | |
| SCHEMBL1164899 | 0.68 | ROCK2 (0.50) | ROCK2NPC1RAB9AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044326-A1 | LACTAMS AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMAPANY (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044326-A1 | LACTAMS AS INHIBITORS OF ROCK | MYLK, ROCK1, RHOA | STK10 352/4885SLK 622/4885ROCK2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.