Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.57 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.57 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.57 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.56 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12042256 | 0.89 | ROCK2 (0.55) | ROCK2ROCK1IMPDH2PRMT3NOTUM | |
| SCHEMBL19860038 | 0.88 | PRMT3 (0.60) | ROCK2ROCK1IMPDH2PRMT3NOTUM | |
| SCHEMBL19860036 | 0.87 | ROCK2 (0.66) | ROCK2ROCK1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL19860037 | 0.86 | NOTUM (0.55) | ROCK2ROCK1IMPDH2PRMT3NOTUM | |
| SCHEMBL11975549 | 0.86 | ROCK2 (0.57) | ROCK2ROCK1IMPDH2PRMT3NOTUM | |
| SCHEMBL14147299 | 0.83 | RAB9A (0.68) | ROCK2ROCK1IMPDH2PRMT3NOTUM | |
| SCHEMBL19859923 | 0.82 | SLC1A3 (0.80) | SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL12201759 | 0.81 | IMPDH2 (0.61) | ROCK2ROCK1IMPDH2PRMT3NOTUM | |
| Hydrochloric Acid SCHEMBL2162309 | 0.80 | IMPDH2 (0.59) | ROCK2ROCK1IMPDH2PRMT3NOTUM | |
| Hydrochloric Acid SCHEMBL3564762 | 0.80 | IMPDH2 (0.59) | ROCK2ROCK1IMPDH2PRMT3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |