Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.64 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.55 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12202000 | 0.85 | NOTUM (0.76) | NOTUMIMPDH2ROCK2PRMT3 | |
| SCHEMBL19860100 | 0.83 | NOTUM (0.65) | NOTUMIMPDH2ROCK2ALDH1A1PRMT3 | |
| SCHEMBL4428374 | 0.83 | NOTUM (0.62) | NOTUMIMPDH2ROCK2PRMT3 | |
| SCHEMBL19860099 | 0.81 | NOTUM (0.64) | NOTUMIMPDH2ROCK2PRMT3 | |
| SCHEMBL12228153 | 0.80 | NOTUM (0.69) | NOTUMIMPDH2MEN1KMT2AMAPT | |
| SCHEMBL19860094 | 0.80 | NOTUM (0.68) | NOTUMIMPDH2ROCK2PRMT3 | |
| SCHEMBL3111893 | 0.79 | IMPDH2 (0.72) | IMPDH2ROCK2ALDH1A1MEN1KMT2A | |
| SCHEMBL3595348 | 0.79 | ROCK2 (0.60) | NOTUMIMPDH2ROCK2ALDH1A1MEN1 | |
| SCHEMBL24735962 | 0.79 | IMPDH2 (0.69) | NOTUMIMPDH2ROCK2ALDH1A1PRMT3 | |
| SCHEMBL12228149 | 0.78 | NOTUM (0.72) | NOTUMIMPDH2ROCK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |