Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.64 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.62 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.57 |
| ▸ | PTPRC | P08575 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12202000 | 0.85 | NOTUM (0.76) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL24735962 | 0.84 | IMPDH2 (0.69) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL12058848 | 0.83 | POLB (0.65) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL14124411 | 0.83 | PRMT3 (0.59) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL19860096 | 0.83 | NOTUM (0.65) | NOTUMIMPDH2PRMT3 | |
| SCHEMBL3566775 | 0.83 | PRMT3 (0.72) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL13913488 | 0.81 | ROCK2 (0.65) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL19860063 | 0.81 | NOTUM (0.64) | NOTUMIMPDH2PRMT3ROCK2 | |
| SCHEMBL2164137 | 0.81 | PRMT3 (0.69) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL4553921 | 0.80 | PRMT3 (0.56) | NOTUMIMPDH2PRMT3ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |