Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | ME2 | P23368 | 1/20 | 0.55 |
| ▸ | ME1 | P48163 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860085 | 0.85 | TERT (0.64) | LMNAALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL2162496 | 0.84 | ALDH1A1 (0.58) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19860084 | 0.84 | IMPDH2 (0.55) | LMNAALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL19860074 | 0.84 | TERT (0.63) | LMNAALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL19860073 | 0.82 | IMPDH2 (0.53) | LMNAALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL14124393 | 0.82 | IMPDH2 (0.52) | LMNAALDH1A1TSHRJAK2JAK3 | |
| SCHEMBL19860086 | 0.80 | GSK3B (0.58) | LMNAALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL14124408 | 0.78 | TERT (0.53) | LMNAALDH1A1TSHRJAK2JAK3 | |
| SCHEMBL12746090 | 0.77 | JAK3 (0.66) | LMNAALDH1A1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL26343148 | 0.76 | MEN1 (0.69) | LMNAALDH1A1TSHRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |