Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.52 |
| ▸ | TERT | O14746 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | WNT1 | P04628 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860086 | 0.96 | GSK3B (0.58) | IMPDH2GSK3BDYRK1ALMNAGAA | |
| SCHEMBL19860085 | 0.89 | TERT (0.64) | IMPDH2GSK3BDYRK1ALMNASMN1; SMN2 | |
| SCHEMBL19860073 | 0.88 | IMPDH2 (0.53) | IMPDH2LMNAALDH1A1TSHRPRMT3 | |
| SCHEMBL19860074 | 0.88 | TERT (0.63) | IMPDH2LMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL14124393 | 0.86 | IMPDH2 (0.52) | IMPDH2GSK3BDYRK1ALMNAALDH1A1 | |
| SCHEMBL2162496 | 0.86 | ALDH1A1 (0.58) | GSK3BDYRK1ALMNAGAASMN1; SMN2 | |
| SCHEMBL19860076 | 0.84 | LMNA (0.61) | IMPDH2LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL14124408 | 0.82 | TERT (0.53) | IMPDH2GSK3BDYRK1ALMNAALDH1A1 | |
| SCHEMBL13621138 | 0.81 | LMNA (0.61) | LMNAGAASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL19860072 | 0.80 | SMN1; SMN2 (0.61) | IMPDH2LMNASMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |