Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | PRMT3 | O60678 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TERT | O14746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860084 | 0.88 | IMPDH2 (0.55) | IMPDH2PRMT3ALDH1A1MEN1KMT2A | |
| SCHEMBL19860085 | 0.87 | TERT (0.64) | IMPDH2PRMT3ALDH1A1KDM4EMEN1 | |
| SCHEMBL19860074 | 0.86 | TERT (0.63) | IMPDH2PRMT3ALDH1A1KDM4EMEN1 | |
| SCHEMBL19860086 | 0.84 | GSK3B (0.58) | IMPDH2PRMT3ALDH1A1KDM4EMEN1 | |
| SCHEMBL14124393 | 0.84 | IMPDH2 (0.52) | IMPDH2PRMT3ALDH1A1TERTLMNA | |
| SCHEMBL2162496 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL19860076 | 0.82 | LMNA (0.61) | IMPDH2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL14124408 | 0.80 | TERT (0.53) | IMPDH2PRMT3ALDH1A1TERTLMNA | |
| SCHEMBL19860072 | 0.78 | SMN1; SMN2 (0.61) | IMPDH2PRMT3ALDH1A1TERTLMNA | |
| SCHEMBL30176801 | 0.78 | KDM4E (0.66) | IMPDH2PRMT3ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |