Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 4/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603765 | 0.85 | PRMT3 (0.56) | PRMT3IMPDH2NOTUMMEN1KMT2A | |
| SCHEMBL2164137 | 0.84 | PRMT3 (0.69) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL19860082 | 0.84 | ROCK1 (0.60) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL3566775 | 0.84 | PRMT3 (0.72) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL16634909 | 0.80 | PRMT3 (0.61) | PRMT3IMPDH2NOTUM | |
| SCHEMBL14124401 | 0.79 | IMPDH2 (0.61) | PRMT3IMPDH2NOTUMROCK2MEN1 | |
| SCHEMBL2162460 | 0.78 | KMT2A (0.67) | ROCK2MEN1KMT2A | |
| SCHEMBL14124382 | 0.78 | JAK2 (0.57) | PRMT3ROCK2MEN1KMT2AROCK1 | |
| SCHEMBL14124306 | 0.78 | PRMT3 (0.66) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL18092568 | 0.78 | ROCK2 (0.59) | PRMT3IMPDH2NOTUMROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |