Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | PRMT3 | O60678 | 4/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860103 | 0.89 | NOTUM (0.56) | NOTUMROCK2PRMT3GALR3NR2F2 | |
| SCHEMBL19860119 | 0.80 | ROCK2 (0.53) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL19860125 | 0.79 | PRMT3 (0.71) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL19860043 | 0.78 | NOTUM (0.63) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL2163047 | 0.77 | NOTUM (0.65) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL19860105 | 0.76 | PRMT3 (0.62) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL2162755 | 0.75 | NOTUM (0.62) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL19860126 | 0.75 | PRMT3 (0.65) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL3586006 | 0.75 | NOTUM (0.69) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL19860124 | 0.74 | IMPDH2 (0.59) | NOTUMPRMT3IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |