Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.63 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 6/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860103 | 0.88 | NOTUM (0.56) | NOTUMIMPDH2ROCK2PRMT3 | |
| SCHEMBL20353587 | 0.85 | IMPDH2 (0.72) | NOTUMIMPDH2ROCK2PRMT3 | |
| SCHEMBL2162616 | 0.84 | IMPDH2 (0.70) | NOTUMIMPDH2ROCK2KDM4EALDH1A1 | |
| SCHEMBL2163047 | 0.81 | NOTUM (0.65) | NOTUMIMPDH2ROCK2NPC1PRMT3 | |
| SCHEMBL19860124 | 0.81 | IMPDH2 (0.59) | NOTUMIMPDH2KDM4EALDH1A1PRMT3 | |
| SCHEMBL19860111 | 0.81 | NOTUM (0.55) | NOTUMIMPDH2ROCK2KDM4EALDH1A1 | |
| SCHEMBL19860110 | 0.81 | IMPDH2 (0.59) | NOTUMIMPDH2ROCK2PRMT3 | |
| SCHEMBL14124390 | 0.79 | NOTUM (0.61) | NOTUMIMPDH2ROCK2ALDH1A1PRMT3 | |
| SCHEMBL19860105 | 0.78 | PRMT3 (0.62) | NOTUMIMPDH2PRMT3 | |
| SCHEMBL19860119 | 0.78 | ROCK2 (0.53) | NOTUMIMPDH2ROCK2PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |