Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15740655 | 0.88 | TRPM8 (0.36) | TRPM8L3MBTL1GAATSHRF2 | |
| SCHEMBL19015200 | 0.87 | TRPM8 (0.33) | TRPM8GAATSHRF2MEN1 | |
| SCHEMBL3654697 | 0.84 | TRPM8 (0.39) | TRPM8L3MBTL1GAATSHRF2 | |
| SCHEMBL6982226 | 0.79 | TRPM8 (0.37) | TRPM8GAATSHRF2MEN1 | |
| SCHEMBL4840789 | 0.79 | PKM (0.40) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL8091312 | 0.75 | ALDH1A1 (0.38) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL12744160 | 0.74 | TRPM8 (0.35) | TRPM8L3MBTL1GAATSHRF2 | |
| SCHEMBL1585657 | 0.74 | FFAR2 (0.43) | TRPM8GAATSHRMETAP1FFAR2 | |
| SCHEMBL27567713 | 0.73 | METAP1 (0.36) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL21505859 | 0.72 | SCN1A (0.53) | TRPM8GAATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890152-B2 | Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants | GENENTECH, INC. (US) | 2018-02-13 | — | — | US | disclosed |