Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654697 | 0.86 | TRPM8 (0.39) | TRPM8GAATSHRGSTO1MEN1 | |
| SCHEMBL4840789 | 0.85 | PKM (0.40) | TRPM8GAATSHRGSTO1MEN1 | |
| SCHEMBL8091312 | 0.79 | ALDH1A1 (0.38) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL19861616 | 0.79 | TRPM8 (0.35) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL3069954 | 0.78 | METAP1 (0.36) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL1585657 | 0.78 | FFAR2 (0.43) | TRPM8GAATSHRFFAR2METAP1 | |
| SCHEMBL15740655 | 0.77 | TRPM8 (0.36) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL27567713 | 0.77 | METAP1 (0.36) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL19015200 | 0.76 | TRPM8 (0.33) | TRPM8GAATSHRMEN1KMT2A | |
| SCHEMBL21505859 | 0.76 | SCN1A (0.53) | TRPM8GAATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289950-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096296-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |