Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PAM | P19021 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19862613 | 0.98 | DGKA (0.61) | DGKADNM1PAOXEPHX2TSHR | |
| SCHEMBL16330783 | 0.96 | DGKA (0.52) | DGKADNM1PAOXEPHX2TSHR | |
| SCHEMBL17525969 | 0.92 | EPHX2 (0.50) | DGKADNM1PAOXEPHX2TSHR | |
| SCHEMBL14174579 | 0.92 | DGKA (0.50) | DGKADNM1PAOXEPHX2TSHR | |
| SCHEMBL14879118 | 0.86 | ADRA2A (0.48) | DGKADNM1EPHX2TSHRALDH1A1 | |
| SCHEMBL4570263 | 0.86 | ADRA2A (0.48) | DGKADNM1EPHX2TSHRALDH1A1 | |
| SCHEMBL16020457 | 0.86 | ADRA2A (0.48) | DGKADNM1EPHX2TSHRALDH1A1 | |
| SCHEMBL16020410 | 0.86 | ADRA2A (0.48) | DGKADNM1EPHX2TSHRALDH1A1 | |
| SCHEMBL14434076 | 0.85 | DGKA (0.55) | DGKADNM1PAOXTSHRALDH1A1 | |
| SCHEMBL14016564 | 0.83 | DGKA (0.59) | DGKADNM1PAOXTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180042996-A1 | Hydrogel-Linked IL-1ra Prodrug | ASCENDIS PHARMA OSTEOARTHRITIS DIVISION A/S (DK) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180042996-A1 | Hydrogel-Linked IL-1ra Prodrug | IL1A, IL1B, IL1R1 | DGKA 2415/4885DNM1 4767/4885PAOX 3508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.