Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | DGKA | P23743 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16020457 | 1.00 | ADRA2A (0.48) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL14879118 | 1.00 | ADRA2A (0.48) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL16020410 | 1.00 | ADRA2A (0.48) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL13635974 | 0.93 | ALDH1A1 (0.56) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL12314639 | 0.92 | ADRA2A (0.42) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL4570264 | 0.92 | MEN1 (0.44) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL16351471 | 0.92 | MEN1 (0.44) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL18252755 | 0.92 | LMNA (0.56) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL16789175 | 0.92 | NAAA (0.44) | ADRA2AADRA1AALDH1A1MAPTBLM | |
| SCHEMBL29333715 | 0.92 | ADRA2A (0.42) | ADRA2AADRA1AALDH1A1MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180042996-A1 | Hydrogel-Linked IL-1ra Prodrug | ASCENDIS PHARMA OSTEOARTHRITIS DIVISION A/S (DK) | 2018-02-15 | — | — | US | disclosed |
| US-9840607-B2 | Polyhydroxy ketal ester adducts, methods of manufacture and uses thereof | GFBIOCHEMICALS LIMITED (MT) | 2017-12-12 | — | — | US | disclosed |
| US-9840607-B2 | Polyhydroxy ketal ester adducts, methods of manufacture and uses thereof | GFBIOCHEMICALS LIMITED (MT) | 2017-12-12 | — | — | US | disclosed |
| US-20160237302-A1 | WATERBORNE COMPOSITIONS | CALLAGHAN INNOVATION RESEARCH LIMITED (NZ) | 2016-08-18 | — | — | US | disclosed |
| US-20160237302-A1 | WATERBORNE COMPOSITIONS | CALLAGHAN INNOVATION RESEARCH LIMITED (NZ) | 2016-08-18 | — | — | US | disclosed |
| US-20160068660-A1 | POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF | GFBIOCHEMICALS LIMITED (MT) | 2016-03-10 | — | — | US | disclosed |
| US-20160068660-A1 | POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF | GFBIOCHEMICALS LIMITED (MT) | 2016-03-10 | — | — | US | disclosed |
| US-9187598-B2 | Polyhydroxy ketal ester adducts, methods of manufacture and uses thereof | SEGETIS, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-9187598-B2 | Polyhydroxy ketal ester adducts, methods of manufacture and uses thereof | SEGETIS, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| WO-2015038012-A1 | WATERBORNE COMPOSITIONS | VICTORIA LINK LIMITED (NZ) | 2015-03-19 | — | — | WO | disclosed |
| WO-2012065116-A2 | POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF | SEGETIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| US-20120121911-A1 | POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF | SEGETIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120121911-A1 | POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF | SEGETIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068660-A1 | POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF | ALKBH3, PHYKPL, KYAT1 | ADRA2A 3820/4885ADRA1A 3942/4885ALDH1A1 1068/4885 |
| US-20120121911-A1 | POLYHYDROXY KETAL ESTER ADDUCTS, METHODS OF MANUFACTURE AND USES THEREOF | ALKBH3, PHYKPL, KYAT1 | ADRA2A 3820/4885ADRA1A 3942/4885ALDH1A1 1068/4885 |
| US-20180042996-A1 | Hydrogel-Linked IL-1ra Prodrug | IL1A, IL1B, IL1R1 | ADRA2A 443/4885ADRA1A 149/4885ALDH1A1 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.