Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 3/20 | 0.35 |
| ▸ | ARNT | P27540 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865278 | 0.83 | EPAS1 (0.34) | EPAS1 | |
| SCHEMBL19865230 | 0.77 | EPAS1 (0.43) | EPAS1ARNT | |
| SCHEMBL19865246 | 0.73 | ARNT (0.34) | EPAS1ARNTRORCSCN9A | |
| SCHEMBL19865445 | 0.71 | EPAS1 (0.49) | EPAS1PTGS1PTGS2 | |
| SCHEMBL19865196 | 0.71 | CCR2 (0.33) | EPAS1PTGS2 | |
| SCHEMBL19865297 | 0.70 | EPAS1 (0.40) | EPAS1 | |
| SCHEMBL19870930 | 0.70 | EPAS1 (0.53) | EPAS1ARNT | |
| SCHEMBL19865338 | 0.70 | EPAS1 (0.33) | EPAS1 | |
| SCHEMBL19865425 | 0.68 | EPAS1 (0.65) | EPAS1ARNT | |
| SCHEMBL18048412 | 0.62 | EPAS1 (0.34) | EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018031680-A1 | NOVEL COMPOUNDS, USES AND METHODS FOR THEIR PREPARATION | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2018-02-15 | — | — | WO | disclosed |