Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.67 |
| ▸ | RAF1 | P04049 | 2/20 | 0.67 |
| ▸ | GCGR | P47871 | 4/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.65 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.57 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20445285 | 0.86 | MAPT (0.64) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL15075611 | 0.85 | MAPK13 (0.89) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| Hydrochloric Acid SCHEMBL23736191 | 0.85 | MAPT (0.63) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7366314 | 0.83 | MAPK13 (0.54) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL9196324 | 0.81 | MAPK11 (0.69) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL19868944 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| Sb-202474 SCHEMBL14492046 | 0.81 | TGFBR1 (0.64) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6469341 | 0.80 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7995495 | 0.79 | MAPK13 (0.63) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6164173 | 0.79 | MAPK13 (0.79) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044316-A1 | POTENTIATORS OF BETA-LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044316-A1 | POTENTIATORS OF BETA-LACTAM ANTIBIOTICS | CREB1, PPP6R1, PPP1R10 | MAPK14 440/4885MAPK13 782/4885MAPK12 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.