Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.64 |
| ▸ | RAF1 | P04049 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23736191 | 0.98 | MAPT (0.63) | MAPTTP53MAPK13MAPK12MAPK11 | |
| SCHEMBL11516210 | 0.87 | MAPK13 (0.53) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19868943 | 0.86 | MAPK14 (0.67) | MAPTTP53MAPK13MAPK12MAPK11 | |
| SCHEMBL1132001 | 0.84 | MAPK13 (0.86) | MAPTTP53MAPK13MAPK12MAPK11 | |
| SCHEMBL15400046 | 0.84 | MAPK13 (0.86) | MAPTTP53MAPK13MAPK12MAPK11 | |
| SCHEMBL8104080 | 0.84 | MAPK13 (0.86) | MAPTTP53MAPK13MAPK12MAPK11 | |
| SCHEMBL1308320 | 0.84 | MAPK13 (0.86) | MAPTTP53MAPK13MAPK12MAPK11 | |
| SCHEMBL7366314 | 0.84 | MAPK13 (0.54) | MAPTTP53MAPK13MAPK12MAPK11 | |
| SCHEMBL23758282 | 0.83 | GAA (0.58) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20425291 | 0.81 | MAPK13 (0.60) | MAPTTP53MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573957-B1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | RIVARA MIRKO (IT) | 2023-04-26 | — | — | EP | disclosed |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | MAPT 183/4885TP53 4250/4885MAPK13 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.