Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.60 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.60 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | B4GALT1 | P15291 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CD69 | Q07108 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23031873 | 1.00 | MAPK1 (0.74) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL19509484 | 1.00 | MAPK1 (0.74) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL26249989 | 1.00 | MAPK1 (0.74) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL25767297 | 1.00 | MAPK1 (0.74) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL22021801 | 1.00 | MAPK1 (0.74) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL16392632 | 0.89 | MAPK1 (0.73) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL16393106 | 0.89 | MAPK1 (0.73) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL2482719 | 0.89 | MAPK1 (0.73) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL24496201 | 0.89 | MAPK1 (0.63) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL10333760 | 0.88 | MAPK1 (0.75) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277401-A1 | Compositions and Methods for Modulating PKK Expression | IONIS PHARMACEUTICALS, INC. (US) | 2021-09-09 | — | — | US | disclosed |
| US-10683499-B2 | Compositions and methods for modulating TTR expression | IONIS PHARMACEUTICALS, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2020-05-21 | — | — | US | disclosed |
| US-20180044676-A1 | COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210277401-A1 | Compositions and Methods for Modulating PKK Expression | GCKR, PKM, PKLR | MAPK1 1377/4885LGALS8 2854/4885LGALS3 3380/4885 |
| US-20180044676-A1 | COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION | TTR, GALNT1, GALNT3 | MAPK1 4758/4885LGALS8 54/4885LGALS3 48/4885 |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | RNASE1, RNASEH1, RNASEL | MAPK1 4321/4885LGALS8 718/4885LGALS3 1198/4885 |
| US-10683499-B2 | Compositions and methods for modulating TTR expression | TTR, GALNT1, GALNT3 | MAPK1 4758/4885LGALS8 54/4885LGALS3 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.