Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 3/20 | 0.43 |
| ▸ | NSD2 | O96028 | 3/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 4/20 | 0.40 |
| ▸ | S100A4 | P26447 | 4/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19901476 | 0.87 | PTPRC (0.43) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL19901472 | 0.78 | PTPN1 (0.36) | PTPRCTDP2PLCG1CES1MEN1 | |
| SCHEMBL802342 | 0.76 | PDK2 (0.36) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL19901466 | 0.69 | MAOA (0.42) | BLMCDC25BALDH1A1 | |
| SCHEMBL19901471 | 0.69 | MAOA (0.42) | BLMCDC25BALDH1A1 | |
| SCHEMBL2604368 | 0.67 | TDP2 (0.56) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL30665385 | 0.67 | TDP2 (0.56) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL12902152 | 0.66 | TSHR (0.48) | CES1 | |
| SCHEMBL829095 | 0.65 | TDP2 (0.52) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL8801062 | 0.65 | GABRA1 (0.56) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2018-06-07 | — | — | US | disclosed |
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | ROCK1, MYLK, ROCK2 | PTPRC 466/4885CTSL 4371/4885CTSS 3463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.