SCHEMBL1990265

SCHEMBL1990265

CC[CH]c1nc(C(F)(F)F)cs1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.37
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
FFAR2 O15552 1/20 0.31
SDHB P21912 1/20 0.31
IDH1 O75874 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2711942 0.78 MEN1 (0.38) LMNAMEN1KMT2AFFAR2IDH1
SCHEMBL13104068 0.73 LMNA (0.38) LMNAMEN1KMT2AFFAR2SDHB
SCHEMBL28860776 0.71 LMNA (0.36) LMNAMEN1KMT2AFFAR2SDHB
SCHEMBL3699294 0.70 FFAR2 (0.36) FFAR2
SCHEMBL343104 0.70 LMNA (0.41) LMNAMEN1KMT2A
SCHEMBL25083766 0.69 LMNA (0.55) LMNAMEN1KMT2AFFAR2
SCHEMBL13064451 0.69 MEN1 (0.35) LMNAMEN1KMT2A
SCHEMBL16592085 0.68 SLC6A3 (0.39) LMNAMEN1KMT2ASDHB
SCHEMBL25006020 0.67 LMNA (0.35) LMNAIDH1
SCHEMBL6266188 0.67 MEN1 (0.35) LMNAMEN1KMT2AFFAR2IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140018377-A1 Aminopropenoates as Fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-01-16 US disclosed
US-8476197-B2 Aminopropenoates as fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-07-02 US disclosed
US-20110152322-A1 Aminopropenoates as Fungicides BAYER CROPSCIENCE AG (DE) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152322-A1 Aminopropenoates as Fungicides AASDHPPT, DAO, AAAS LMNA 1991/4885MEN1 1882/4885KMT2A 979/4885
US-20140018377-A1 Aminopropenoates as Fungicides ACMSD, AASDHPPT, AAAS LMNA 2687/4885MEN1 2379/4885KMT2A 1020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.