Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11452798 | 0.87 | NPC1 (0.48) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28573597 | 0.83 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL19902764 | 0.78 | NPSR1 (0.46) | RAB9ANPC1SMN1; SMN2MAPTLMNA | |
| SCHEMBL19902763 | 0.77 | SGMS2 (0.40) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5763437 | 0.75 | CLCN2 (0.41) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28614091 | 0.75 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6961935 | 0.74 | GAA (0.46) | ALDH1A1MAPTKMT2AHTT | |
| SCHEMBL19902804 | 0.74 | BLM (0.39) | ALDH1A1MAPTPOLBLMNA | |
| SCHEMBL6155127 | 0.73 | SRC (0.53) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4860965 | 0.72 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |