Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902764 | 0.86 | NPSR1 (0.46) | SGMS2HTTHSD17B10MAPTNPSR1 | |
| SCHEMBL11452798 | 0.83 | NPC1 (0.48) | HTTHSD17B10MAPTSMN1; SMN2NPC1 | |
| SCHEMBL16491931 | 0.79 | RAB9A (0.44) | HSD17B10MAPTNPSR1SMN1; SMN2NPC1 | |
| SCHEMBL19902737 | 0.77 | RAB9A (0.54) | HTTMAPTNPSR1SMN1; SMN2NPC1 | |
| SCHEMBL28858026 | 0.74 | RAB9A (0.40) | MAPTSMN1; SMN2NPC1RAB9AKDR | |
| SCHEMBL5763437 | 0.72 | CLCN2 (0.41) | HTTF2RMAPTSMN1; SMN2NPC1 | |
| SCHEMBL6961935 | 0.71 | GAA (0.46) | HTTF2RMAPTHPGDALDH1A1 | |
| SCHEMBL19902804 | 0.70 | BLM (0.39) | F2RMAPTHPGDALDH1A1GAA | |
| SCHEMBL19902767 | 0.70 | RAB9A (0.44) | NPSR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL459529 | 0.67 | P4HTM (0.42) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |