Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902763 | 0.86 | SGMS2 (0.40) | NPSR1SGMS2HTTSMN1; SMN2SLC6A2 | |
| SCHEMBL11452798 | 0.81 | NPC1 (0.48) | HTTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL16491932 | 0.79 | KMT2A (0.48) | NPSR1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL19902737 | 0.78 | RAB9A (0.54) | NPSR1HTTSMN1; SMN2LMNANPC1 | |
| SCHEMBL2242286 | 0.71 | NPSR1 (0.57) | NPSR1PIK3CAMTORSORT1KCNQ3 | |
| SCHEMBL30919458 | 0.71 | NPSR1 (0.57) | NPSR1PIK3CAMTORSORT1KCNQ3 | |
| SCHEMBL22323774 | 0.71 | MEN1 (0.67) | SGMS2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL19902804 | 0.71 | BLM (0.39) | LMNAMAPT | |
| SCHEMBL25143492 | 0.71 | HPGD (0.63) | PIK3CAMTORSORT1HTTTYK2 | |
| SCHEMBL31665584 | 0.71 | HPGD (0.63) | PIK3CAMTORSORT1HTTTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |