Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tedizolid Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 12/20 | 0.79 |
| ▸ | MAOB | P27338 | 2/20 | 0.79 |
| ▸ | CALML3 | P27482 | 6/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tedizolid Phosphate SCHEMBL29377855 | 1.00 | MAOA (0.79) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| Tedizolid Phosphate SCHEMBL29766931 | 1.00 | MAOA (0.79) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| Tedizolid Phosphate SCHEMBL1557561 | 1.00 | MAOA (0.79) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| SCHEMBL20216092 | 0.96 | MAOA (0.81) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| SCHEMBL13144441 | 0.96 | MAOA (0.81) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| SCHEMBL1990275 | 0.95 | MAOA (0.82) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| SCHEMBL13144426 | 0.95 | MAOA (0.76) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| SCHEMBL2189136 | 0.95 | MAOA (0.76) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| SCHEMBL12997802 | 0.95 | MAOA (0.78) | MAOAMAOBCALML3CYP2C19CYP2C9 | |
| SCHEMBL12997803 | 0.95 | MAOA (0.78) | MAOAMAOBCALML3CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444275-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE SUBSTANCES IN NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2024-10-16 | — | — | EP | claimed |
| WO-2023104380-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE SUBSTANCES IN NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2023-06-15 | — | — | WO | claimed |
| EP-4190312-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE AGENTS INTO NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2023-06-07 | — | — | EP | claimed |
| EP-1699784-B1 | NOVEL OXAZOLIDINONE DERIVATIVES | DONG A PHARM CO LTD (KR) | 2011-06-29 | — | — | EP | claimed |
| CN-120001315-A | Texazolamide phosphate preparation device for injection | 安徽省诚联医药科技有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-119701726-A | Preparation device of tedizolid key intermediate | 苏州艾培瑞生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |
| EP-4444275-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE SUBSTANCES IN NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2024-10-16 | — | — | EP | disclosed |
| CN-117959311-A | Application of tedizolid phosphate in preparation of cisplatin-resistant ototoxic drugs | 山东第一医科大学(山东省医学科学院) | 2024-05-03 | — | — | CN | disclosed |
| CN-115385959-B | High-purity tedizolid phosphate and preparation method thereof | 浙江尖峰药业有限公司 | 2023-07-28 | — | — | CN | disclosed |
| WO-2023104380-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE SUBSTANCES IN NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2023-06-15 | — | — | WO | disclosed |
| CN-116253711-A | Texazolamide phosphate intermediate and preparation method thereof | 浙江苏泊尔制药有限公司 | 2023-06-13 | — | — | CN | disclosed |
| EP-4190312-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE AGENTS INTO NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2023-06-07 | — | — | EP | disclosed |
| CN-105837634-B | Tedizolid phosphate crystal and preparation method thereof | 上海创诺制药有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-106146485-A | A kind of method preparing safe ground azoles amine and the safe ground azoles amine crystalline solid obtained thereof | 上海创诺医药集团有限公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-105985331-A | Process for preparing tedizolid | 上海医药工业研究院 | 2016-10-05 | — | — | CN | disclosed |
| CN-105859780-A | Method for preparing tedizolid phosphate | 山东康美乐医药科技有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105837634-A | Tedizolid phosphate crystal and preparation method thereof | 上海创诺制药有限公司 | 2016-08-10 | — | — | CN | disclosed |
| US-20140057874-A1 | OXAZOLIDINONE CONTAINING DIMER COMPOUNDS, COMPOSITIONS AND METHODS TO MAKE AND USE | TRIUS THERAPEUTICS, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-8580767-B2 | Oxazolidinone containing dimer compounds, compositions and methods to make and use | TRIUS THERAPEUTICS, INC. (US) | 2013-11-12 | — | — | US | disclosed |
| WO-2010138649-A1 | OXAZOLIDINONE CONTAINING DIMER COMPOUNDS, COMPOSITIONS AND METHODS TO MAKE AND USE | TRIUS THERAPEUTICS, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140057874-A1 | OXAZOLIDINONE CONTAINING DIMER COMPOUNDS, COMPOSITIONS AND METHODS TO MAKE AND USE | NR1I2, NR1D2, NR1D1 | MAOA 3015/4885MAOB 2265/4885CALML3 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.