Tedizolid Phosphate

Tedizolid Phosphate

SCHEMBL1557561

Cn1nnc(-c2ccc(-c3ccc(N4C[C@H](COP(=O)(O)O)OC4=O)cc3F)cn2)n1

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Tedizolid Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAOA P21397 12/20 0.79
MAOB P27338 2/20 0.79
CALML3 P27482 6/20 0.48
CYP2C19 P33261 2/20 0.46
CYP2C9 P11712 1/20 0.46
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tedizolid Phosphate SCHEMBL1990278 1.00 MAOA (0.79) MAOAMAOBCALML3CYP2C19CYP2C9
Tedizolid Phosphate SCHEMBL29377855 1.00 MAOA (0.79) MAOAMAOBCALML3CYP2C19CYP2C9
Tedizolid Phosphate SCHEMBL29766931 1.00 MAOA (0.79) MAOAMAOBCALML3CYP2C19CYP2C9
SCHEMBL20216092 0.96 MAOA (0.81) MAOAMAOBCALML3CYP2C19CYP2C9
SCHEMBL13144441 0.96 MAOA (0.81) MAOAMAOBCALML3CYP2C19CYP2C9
SCHEMBL1990275 0.95 MAOA (0.82) MAOAMAOBCALML3CYP2C19CYP2C9
SCHEMBL13144426 0.95 MAOA (0.76) MAOAMAOBCALML3CYP2C19CYP2C9
SCHEMBL2189136 0.95 MAOA (0.76) MAOAMAOBCALML3CYP2C19CYP2C9
SCHEMBL12997802 0.95 MAOA (0.78) MAOAMAOBCALML3CYP2C19CYP2C9
SCHEMBL12997803 0.95 MAOA (0.78) MAOAMAOBCALML3CYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10442829-B2 Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate MERCK SHARP & DOHME CORP. (US) 2019-10-15 US claimed
EP-2393808-B1 CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE MERCK SHARP & DOHME (US) 2019-05-08 EP claimed
US-10189870-B2 Crystalline form of oxazolidinone antibiotics and preparation method, composition and use thereof HANGZHOU PUSHAI PHARMAEUTICAL TECHNOLOGY CO., LTD. (CN) 2019-01-29 US claimed
US-10065947-B1 Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate MERCK SHARP & DOHME CORP. (US) 2018-09-04 US claimed
US-20180244704-A1 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE MERCK SHARP & DOHME LLC 2018-08-30 US claimed
US-9988406-B2 Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate MERCK SHARP & DOHME CORP. (US) 2018-06-05 US claimed
US-20170275315-A1 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE MERCK SHARP & DOHME LLC 2017-09-28 US claimed
US-9624250-B2 Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate MERCK SHARP & DOHME CORP. (US) 2017-04-18 US claimed
US-20160176905-A1 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE MERCK SHARP & DOHME LLC 2016-06-23 US claimed
US-20130310343-A1 CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN- 5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE TRIUS THERAPEUTICS, INC. (US) 2013-11-21 US claimed
US-8426389-B2 Crystalline form of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate TRIUS THERAPEUTICS, INC. (US) 2013-04-23 US claimed
EP-2393808-A1 CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE Trius Therapeutics (US) 2011-12-14 EP claimed
EP-1699784-B1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A PHARM CO LTD (KR) 2011-06-29 EP claimed
US-7816379-B2 Antibiotics with improved solubility, lower toxicity; potent antibacterial activity; includes torezolid phosphate DONG-A PHARM. CO., LTD. (KR) 2010-10-19 US claimed
US-20100227839-A1 CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN- 5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE TRIUS THERAPEUTICS (US) 2010-09-09 US claimed
WO-2010091131-A1 CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE TRIUS THERAPEUTICS (US) 2010-08-12 WO claimed
US-20090192197-A1 Antibiotics with improved solubility, lower toxicity; potent antibacterial activity; includes Torezolid phosphate DONG-A PHARM. CO., LTD. (KR) 2009-07-30 US claimed
US-20070155798-A1 Antibiotics with improved solubility, lower toxicity; potent antibacterial activity; includes torezolid phosphate DONG-A PHARM. CO., LTD. 2007-07-05 US claimed
CN-115873036-A Synthetic method of tedizolid phosphate 中国药科大学 2023-03-31 CN disclosed
WO-2005058886-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG-A PHARM.CO.,LTD. (KR) 2005-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180244704-A1 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE ALPI, PYGL, PYGM MAOA 2612/4885MAOB 3066/4885CALML3 1240/4885
US-10065947-B1 Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate ALPI, PYGL, PYGM MAOA 2612/4885MAOB 3066/4885CALML3 1240/4885
US-20100227839-A1 CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN- 5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE ALPI, PYGL, PYGM MAOA 2392/4885MAOB 2957/4885CALML3 1201/4885
US-10442829-B2 Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate ALPI, PYGL, PYGM MAOA 2612/4885MAOB 3066/4885CALML3 1240/4885
US-20070155798-A1 Antibiotics with improved solubility, lower toxicity; potent antibacterial activity; includes torezolid phosphate ALPI, SI, TST MAOA 4398/4885MAOB 4248/4885CALML3 1992/4885
US-20090192197-A1 Antibiotics with improved solubility, lower toxicity; potent antibacterial activity; includes Torezolid phosphate ALPI, TPI1, SI MAOA 3819/4885MAOB 3591/4885CALML3 2192/4885
US-20170275315-A1 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE ALPI, PYGL, PYGM MAOA 2612/4885MAOB 3066/4885CALML3 1240/4885
US-20130310343-A1 CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN- 5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE ALPI, PYGL, PYGM MAOA 2482/4885MAOB 2923/4885CALML3 1189/4885
US-10189870-B2 Crystalline form of oxazolidinone antibiotics and preparation method, composition and use thereof OXA1L, PDCD2L, NOD2 MAOA 822/4885MAOB 915/4885CALML3 2797/4885
US-20160176905-A1 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE ALPI, PYGL, PYGM MAOA 2612/4885MAOB 3066/4885CALML3 1240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.