Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SOD1 | P00441 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24690258 | 0.89 | GPR84 (0.44) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL20409004 | 0.85 | KMT2A (0.35) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL30973422 | 0.84 | SOD1 (0.37) | KDM4EALDH1A1HPGDL3MBTL1GPR84 | |
| SCHEMBL30973525 | 0.84 | SOD1 (0.37) | KDM4EALDH1A1HPGDL3MBTL1GPR84 | |
| SCHEMBL16961046 | 0.83 | FAAH (0.42) | L3MBTL1GPR84SCN9A | |
| SCHEMBL13699127 | 0.83 | TP53 (0.44) | ALDH1A1L3MBTL1GPR84SCN9ASOD1 | |
| SCHEMBL16094031 | 0.81 | HTT (0.42) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL1012090 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL19399855 | 0.81 | MEN1 (0.45) | KDM4EALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL3440051 | 0.81 | MEN1 (0.49) | KDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970134-B1 | PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2018-02-28 | — | — | EP | disclosed |