Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19905858 | 0.92 | USP2 (0.38) | DYRK1AMCHR1WNT1GSK3BHRH4 | |
| SCHEMBL19905818 | 0.91 | DYRK1A (0.42) | DYRK1AMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL19905854 | 0.90 | MET (0.39) | DYRK1ARAB9AMAPTHTR2AHTR2C | |
| SCHEMBL19906164 | 0.88 | DYRK1A (0.40) | DYRK1ARAB9AMAPTHTR2AHTR2C | |
| SCHEMBL19905981 | 0.86 | DYRK1A (0.39) | DYRK1AMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL19906287 | 0.85 | KDR (0.37) | — | |
| SCHEMBL17547119 | 0.84 | USP2 (0.38) | DYRK1AMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL19906190 | 0.84 | MAPT (0.39) | DYRK1AMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL19905896 | 0.84 | ALDH1A1 (0.38) | KCNH2 | |
| SCHEMBL19906195 | 0.83 | CASP3 (0.37) | RAB9AMAPTHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070081-B1 | BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES INC (US) | 2018-02-28 | — | — | EP | disclosed |